grief

pesar2.

1. m. Sentimiento o dolor interior que molesta y fatiga el ánimo.

2. m. Dicho o hecho que causa sentimiento o disgusto.

3. m. Arrepentimiento o dolor de los pecados o de otra cosa mal hecha.

a ~, o a ~ de.

1. locs. conjunts. Contra la voluntad o gusto de las personas y, por ext., contra la fuerza o resistencia de las cosas. Lo haré a pesar tuyo, de cuantos quieran impedirlo, del cariño que te profeso, de ser ya muy anciano.

a ~ de los pesares.

1. loc. adv. A pesar de todo, a pesar de todos los obstáculos.
Fuente: Diccionario de la Real Academia Española

The mother was so afflicted at the loss of a fine boy, . . . that she died for grief of it. --Addison.
[1913 Webster]

2. Cause of sorrow or pain; that which afficts or distresses; trial; grievance.
[1913 Webster]

Be factious for redress of all these griefs. --Shak. [1913 Webster]

3. Physical pain, or a cause of it; malady. R. [1913 Webster]

This grief (cancerous ulcers) hastened the end of that famous mathematician, Mr. Harriot. --Wood.
[1913 Webster]

To come to grief, to meet with calamity, accident, defeat, ruin, etc., causing grief; to turn out badly. [Colloq.]

Syn: Affiction; sorrow; distress; sadness; trial; grievance.

Usage: Grief, Sorrow, Sadness. Sorrow is the generic term; grief is sorrow for some definite cause -- one
which commenced, at least, in the past; sadness is
applied to a permanent mood of the mind. Sorrow is
transient in many cases; but the grief of a mother for
the loss of a favorite child too often turns into
habitual sadness. ``Grief is sometimes considered as
synonymous with sorrow; and in this case we speak of
the transports of grief. At other times it expresses
more silent, deep, and painful affections, such as are
inspired by domestic calamities, particularly by the
loss of friends and relatives, or by the distress,
either of body or mind, experienced by those whom we
love and value. --Cogan. See {Affliction}.
[1913 Webster]

Source: The Collaborative International Dictionary of English